Healthy Inc > Blog > Antihistamine manufacturer India
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What is Loratadine 10mg used for?

In the pharmaceutical industry, Loratadine 10 mg is a blockbuster second-generation antihistamine. As a pharmacist and manufacturer, I classify Loratadine as a “non-sedating” H1-receptor antagonist. Its major technical advantage over first-generation antihistamines (like Chlorpheniramine) is its inability to cross the blood-brain barrier in significant amounts, providing allergy relief without the intense drowsiness.

Primary Clinical Uses

  • Allergic Rhinitis (Hay Fever): Relieves symptoms such as sneezing, runny nose, and itchy/watery eyes caused by seasonal or perennial allergens (pollen, dust, pet dander).

  • Chronic Urticaria (Hives): Treatment of itchy skin rashes and wheals associated with chronic idiopathic urticaria.

  • Allergic Conjunctivitis: Reduces redness and itching of the eyes due to allergic reactions.

  • Insect Bites: Can be used to manage localized allergic swelling and itching from stings or bites.

Mechanism of Action: Peripheral H1 Blockade

Loratadine works by selectively competing with free histamine for binding at the H1-receptor sites.

Selective Antagonism: It has a high affinity for peripheral H1 receptors found in the respiratory tract, blood vessels, and skin.

Inhibition of the Allergic Cascade: By blocking these receptors, it prevents histamine from causing vasodilation, increased capillary permeability (which causes the runny nose), and nerve stimulation (which causes itching and sneezing).

Long-Acting Profile: Loratadine is metabolized in the liver into Desloratadine, an active metabolite with a very long half-life, allowing for convenient once-daily (24-hour) dosing.

The Manufacturer’s Perspective: Formulation & Export

From a production and global trade standpoint, Loratadine 10 mg is a high-volume “Consumer Healthcare” staple:

  • Non-Sedating USP: When promoting this on your digital platforms, the “non-drowsy” profile is your primary marketing angle for B2B buyers looking for worker-safe or student-safe allergy medications.

  • Formulation Stability: Loratadine is relatively stable but sensitive to moisture. At our WHO-GMP facility, we utilize Alu-Alu or high-barrier PVC/PVDC blister packaging to ensure a 36-month shelf life for export to Zone IVb regions (Africa, SE Asia).

  • Dissolution and Bioavailability: We optimize the choice of disintegrants to ensure the 10 mg tablet meets strict BP/USP/IP dissolution standards, ensuring rapid onset of action (typically within 1–3 hours).

  • B2B & Dossier Support: As an essential OTC (Over-The-Counter) product, we provide full CTD/eCTD Dossiers to support international registration against the innovator (Claritin).

Loratidine Tablets

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What is Levocetirizine 5 mg tablet used for?

In the pharmaceutical industry, Levocetirizine Dihydrochloride 5 mg is a highly potent, third-generation non-sedating antihistamine. As a pharmacist and manufacturer, I view Levocetirizine as the refined, active R-enantiomer of Cetirizine. It offers higher affinity for $H_1$ receptors, which allows for a smaller dose (5 mg vs. 10 mg) and a significantly lower risk of drowsiness.

Primary Clinical Uses

  • Allergic Rhinitis: Effective for both seasonal (hay fever) and perennial allergies. It relieves symptoms like sneezing, rhinorrhea (runny nose), and nasal congestion.

    Allergic Conjunctivitis: Reduces red, itchy, and watery eyes caused by environmental allergens like pollen, dust mites, or pet dander.

  • Chronic Idiopathic Urticaria: The primary treatment for long-term hives and skin itching, providing relief from wheals and redness.

  • Allergic Dermatitis: Used to manage itching associated with eczema or insect bites.

Mechanism of Action: High-Affinity $H_1$ Blockade

Levocetirizine is an inverse agonist that targets the peripheral histamine $H_1$ receptors.

Selective Binding: It selectively binds to $H_1$ receptors, preventing histamine—the primary mediator of the “allergic cascade”—from attaching.

Stabilization: It stabilizes the receptor in its inactive state, reducing capillary permeability and decreasing the inflammatory response (swelling and mucus production).

Peripheral Action: Because it has low lipid solubility and is a substrate for the P-glycoprotein pump, it does not easily cross the blood-brain barrier, which is why it is “non-sedating” for most patients.

The Manufacturer’s Perspective: Formulation & Export

From a production and global trade standpoint, Levocetirizine 5 mg is a high-demand, high-volume “essential” product:

  • Enantiomeric Purity: As a WHO-GMP manufacturer, we ensure the complete separation of the (R)-enantiomer. This purity is what gives Levocetirizine its superior safety profile over older antihistamines.

  • Formulation Varieties: For your B2B marketplace, we manufacture these as Immediate Release (IR) tablets, Mouth Dissolving Tablets (MDT), and Syrups for pediatric export.

  • Stability for Global Trade: Levocetirizine is highly stable. We utilize Alu-Alu or high-barrier PVC/PVDC blister packaging to ensure a 36-month shelf life for export to Zone IVb regions (Africa and Southeast Asia).

  • Dossier Support: This is a staple for pharmacy chains and distributors. Our Mumbai facility provides full CTD/eCTD Dossiers to support international registration against the innovator (Xyzal).

Levocetirizine Tablets

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