In the pharmaceutical industry, Chlorpromazine Hydrochloride 25 mg is the prototypical first-generation (typical) antipsychotic of the phenothiazine class. As a pharmacist, I characterize Chlorpromazine as a “low-potency” antipsychotic that is highly versatile due to its multi-receptor blocking profile, making it useful far beyond psychiatry.

Primary Clinical Uses

• Psychotic Disorders: Management of schizophrenia and the manic phase of bipolar disorder, particularly for controlling agitation and aggressive behavior.

• Severe Nausea and Vomiting: Used as a potent antiemetic, especially for intractable nausea caused by advanced illness or certain medications.

• Intractable Hiccups: It is one of the few medications specifically indicated for the treatment of hiccups that have persisted for days or weeks.

• Acute Intermittent Porphyria: Used as part of the clinical management of this rare metabolic disorder.

• Pre-operative Sedation: Occasionally used to reduce anxiety and induce sedation before surgery.

Mechanism of Action

Chlorpromazine is a “dirty drug” in pharmacological terms—meaning it acts on a wide variety of receptors, which explains its diverse clinical effects:

Dopamine Antagonism: It blocks D2​ receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ). By inhibiting dopamine overactivity, it reduces “positive” symptoms of psychosis and provides antiemetic effects.

H1-Receptor Blockade: Its action on histamine receptors leads to significant sedation, useful for acute agitation.

Alpha-Adrenergic Blockade: This can lead to cardiovascular effects like orthostatic hypotension.

Muscarinic Blockade: Its anticholinergic effects can cause dry mouth and blurred vision.

The Manufacturer’s Perspective: Formulation & Export

From a manufacturing and global trade standpoint, Chlorpromazine 25 mg is a specialized CNS (Central Nervous System) product:

• Photosensitivity Management: Chlorpromazine API is highly sensitive to light. As a WHO-GMP manufacturer, we utilize amber-colored glass bottles or opaque blister packaging to ensure chemical stability.

• Dose Uniformity: Because 25 mg is a relatively low dose for this molecule, we utilize validated wet granulation and blending processes to ensure absolute content uniformity across every batch.

• Global Export Stability: It remains a staple for psychiatric hospitals and government tenders in the CIS, Africa, and Southeast Asia. We provide the CTD/eCTD Dossiers and stability data required for international registration.

• Regulatory Standards: We ensure all batches comply with BP/USP/IP monographs, specifically monitoring for degradation products like Chlorpromazine Sulfoxide.