What is Metoclopramide 10mg used for?
In the pharmaceutical industry, Metoclopramide 10 mg is a potent dopamine receptor antagonist and prokinetic agent. As a pharmacist and manufacturer, I classify this as a “pro-motility” drug. It is a dual-action molecule that works both centrally (in the brain) and peripherally (in the gut) to speed up digestion and suppress the urge to vomit.
Primary Clinical Uses
-
Nausea and Vomiting: Used to prevent or treat emesis induced by chemotherapy, radiation therapy, surgery, or acute migraines.
-
Gastroesophageal Reflux Disease (GERD): Prescribed for patients who do not respond to standard acid-suppressing therapy; it helps by strengthening the lower esophageal sphincter.
-
Diabetic Gastroparesis: A vital treatment for “stomach paralysis” in diabetic patients, where it stimulates the stomach to empty more quickly into the intestines.
-
Facilitation of Intubation: Used in hospital settings to help clear the stomach before small bowel intubation or radiological examinations.
Mechanism of Action: The Dual Pathway
Metoclopramide exerts its effect through two primary neurotransmitter pathways:
Dopamine Antagonism: In the Chemoreceptor Trigger Zone (CTZ) of the brain, it blocks dopamine receptors. This directly inhibits the signal that triggers nausea and vomiting.
Cholinergic Stimulation: In the upper gastrointestinal tract, it sensitizes tissues to acetylcholine.
The Result: It increases the tone and amplitude of gastric contractions, relaxes the pyloric sphincter, and increases peristalsis of the duodenum and jejunum.
The Manufacturer’s Perspective: Technical & Export
From a production standpoint at a WHO-GMP facility, Metoclopramide 10 mg requires careful professional oversight:
-
The “Fast-Track” USP: On your digital platforms, you can market Metoclopramide as a “prokinetic stabilizer.” It is a high-volume, cost-effective staple for any B2B pharmacy portfolio.
-
Photosensitivity: Metoclopramide is sensitive to light. As a firm owner, you know that the API can degrade if exposed. We utilize Amber-colored PVC or Alu-Alu blister packaging to maintain a 36-month shelf life for export to Zone IVb regions.
-
Safety & Regulatory Compliance: Metoclopramide carries a “Black Box Warning” for Tardive Dyskinesia (involuntary movements) if used for more than 12 weeks. Your Product Information Leaflet (PIL) and website content must reflect these safety guidelines to meet international regulatory standards.
Dossier Support: Our Mumbai-based facility provides full CTD/eCTD Dossiers and dissolution profiles against the innovator (Reglan) to support your firm’s international registration efforts.