Description

Ticagrelor Tablets

Healthy Inc is a specialized global supplier and exporter of advanced cardiovascular, hematological, and acute coronary therapeutics. We provide ultra-high-purity, kinetically precise Ticagrelor Film-Coated Tablets (60 mg / 90 mg), manufactured in WHO–GMP certified, high-capacity oral solid dosage facilities. This “Direct-Acting Reversible P2Y12 Antagonist” is a high-value, premium export to cardiac catheterization labs, intensive care units, outpatient cardiology networks, and government health ministries in LATAM, the Middle East, Africa, and Southeast Asia, serving as the globally mandated, superior intervention for the prevention of atherothrombotic events in patients with Acute Coronary Syndrome (ACS).

Product Overview

This formulation contains Ticagrelor, a cyclopentyltriazolopyrimidine (CPTP) class antiplatelet agent that fundamentally outperforms older thienopyridines by offering a faster, more predictable, and fully reversible blockade of blood clotting.

The “Next-Generation Platelet Inhibitor” Specialist:

• Mechanism (Direct P2Y12 Blockade): During a heart attack (myocardial infarction) or stent placement, blood platelets become hyperactive, clumping together to form deadly clots that block arteries. Ticagrelor violently binds to the P2Y12 ADP receptor on the surface of these platelets, physically paralyzing their ability to clump together (aggregate) and preventing further ischemic damage to the heart.
• The Clopidogrel Upgrade (No Genetic Resistance): Older drugs like Clopidogrel are “prodrugs”—they are inactive when swallowed and rely entirely on the liver’s CYP2C19 enzyme to become active. Millions of patients genetically lack this enzyme and receive zero protection from Clopidogrel. Ticagrelor is active the moment it is absorbed. It requires zero hepatic activation, guaranteeing rapid, life-saving platelet inhibition for 100% of the patient population.
• The Reversible Advantage: Older antiplatelets permanently destroy the platelet for its entire 10-day lifespan. If a patient requires emergency bypass surgery, they risk bleeding to death. Ticagrelor binds reversibly. If the drug is stopped, normal platelet function recovers much faster, drastically improving safety during emergency surgical interventions.

Product Composition & Strength

We supply this product as a Precision-Blended Film-Coated Tablet, packed in highly secure, moisture-resistant Alu-Alu blister strips to ensure the absolute stability of the highly sensitive active pharmaceutical ingredient across all global climate zones.

*Pack Sizes: 10×10 or 14×4 Alu-Alu Blisters (Optimized for strict, twice-daily chronic cardiology adherence regimens).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Cardiology Distributors, and Hospital Procurement Boards.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Critical-Care Kinetic Validation: Because Ticagrelor is deployed during active, life-threatening heart attacks, delayed absorption is clinically unacceptable. Our facilities utilize advanced high-shear granulation and strictly validated multipoint dissolution profiling to guarantee that every tablet disperses immediately, flooding the bloodstream to halt platelet aggregation within 30 minutes of dosing.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of severe cardiovascular disease:

• Acute Coronary Syndrome (ACS): To reduce the rate of cardiovascular death, myocardial infarction (MI), and stroke in patients with ACS (unstable angina, NSTEMI, or STEMI).
• Coronary Stenting: To reduce the rate of stent thrombosis in patients who have been treated with percutaneous coronary intervention (PCI).
• History of MI: Extended treatment (60mg) to reduce the risk of a first or subsequent atherothrombotic event in patients with a history of MI and at high risk of developing an atherothrombotic event.

Dosage & Administration

Recommended Dosage (Strictly as per Cardiologist Guidelines):

• Acute Initiation (Loading Dose): Treatment is typically initiated with a massive, one-time 180 mg loading dose (two 90 mg tablets).
• Standard Maintenance: 90 mg taken twice daily for the first year, followed by 60 mg taken twice daily for extended protection.
• Administration (THE ASPIRIN LIMITATION RULE – CRITICAL): Ticagrelor is always prescribed alongside daily Aspirin. However, maintenance doses of Aspirin exceeding 100 mg per day completely destroy Ticagrelor’s clinical effectiveness. Patients must strictly be maintained on a low-dose aspirin regimen (e.g., 75 mg to 100 mg daily).

Safety Warnings (CRITICAL Regulatory & Clinical Data):

• BLACK BOX WARNING (Bleeding Risk): Ticagrelor, like all powerful antiplatelets, can cause significant, sometimes fatal bleeding. It is strictly contraindicated in patients with active pathological bleeding (like a peptic ulcer) or a history of intracranial hemorrhage. Do not start Ticagrelor in patients planned to undergo urgent coronary artery bypass graft (CABG) surgery.
• Dyspnea (Shortness of Breath): Up to 14% of patients taking Ticagrelor experience an unexplained, intense feeling of shortness of breath (dyspnea) without any actual decline in lung or heart function. Patients must be counseled that this is a unique side effect of the drug, not a secondary heart attack, to prevent unnecessary emergency room visits and drug discontinuation.
• Bradycardia & Heart Blocks: Ticagrelor can occasionally cause severe slowing of the heart rate (bradycardia) and ventricular pauses. It should be used with extreme caution in patients with sick sinus syndrome or high-degree AV blocks without a pacemaker.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Retail Pharmacy Networks. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Cardiovascular Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for cardiac catheterization labs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Specialty Medicine Wholesaler receives WHO-GMP certified products at competitive rates.