Description
Rifampicin Tablets
Healthy Inc is a specialized global supplier and exporter of First-Line Anti-Tubercular Drugs (ATD). We provide high-bioavailability Rifampicin Tablets (and Capsules), sourced from WHO–GMP certified solid dosage facilities. This “Cornerstone of TB Therapy” is a top export to National Tuberculosis Elimination Programs (NTEP), DOTS centers, and NGO-run infectious disease clinics in Africa, LATAM, and Southeast Asia, serving as the most potent sterilizing agent in the fight against Mycobacterium tuberculosis.
Product Overview
This formulation contains Rifampicin, a semi-synthetic macrocyclic antibiotic derived from Amycolatopsis rifamycinica.
The “Sterilizing Powerhouse” Specialist:
- Mechanism: Rifampicin is bactericidal. It binds specifically to the beta-subunit of the bacterial DNA-dependent RNA polymerase enzyme. By blocking the channel where the newly forming RNA chain exits, it physically inhibits the initiation of RNA synthesis (transcription), effectively shutting down the bacteria’s ability to produce proteins and replicate.
- Sterilizing Activity: Unlike other TB drugs that only kill actively dividing bacteria, Rifampicin is unique in its ability to kill semi-dormant “persister” bacteria that metabolize slowly. This property is what allows TB treatment to be shortened from 18 months to 6 months.
- Broad Spectrum: Beyond TB, it is highly effective against Leprosy (Hansen’s Disease), Brucellosis, and resistant Staphylococcal infections (biofilm penetration).
Product Composition & Strength
We supply this product as Film Coated Tablets (Red/Brown) or Hard Gelatin Capsules. The formulation is micronized to ensure peak plasma concentration within 2 hours.
| Active Ingredient | Strength (Standard) | Therapeutic Role | |
|---|---|---|---|
| Rifampicin IP/BP/USP | 150 mg | Pediatric TB / Prophylaxis | |
| Rifampicin IP/BP/USP | 300 mg | Adult Standard / Leprosy | |
| Rifampicin IP/BP/USP | 450 mg / 600 mg | High Dose / Weight > 50kg | |
| Excipients | Q.S. | Sodium Ascorbate | Antioxidant Stabilizer |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 100s, or Bulk HDPE Jars of 1000s (Hospital/Tender Packs).
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.20.99 (Medicaments containing antibiotics) |
| Dosage Form | Tablet (Film Coated) or Capsule |
| Packaging | Alu-Alu Blister (Oxygen Sensitive) |
| Storage | Store below 25°C. Protect from Moisture and Air. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Oxidation Prevention: Rifampicin is highly unstable in the presence of oxygen (oxidizes to Rifampicin Quinone). Our manufacturing line uses nitrogen purging during blending and blistering to ensure the drug retains its potency throughout its shelf life.
- Dissolution: Bioavailability is critical for TB cure rates. Our tablets are engineered to disintegrate rapidly in the acidic environment of the stomach to ensure maximum absorption before food interferes.
Therapeutic Indications (Human Use)
Indicated for the treatment of mycobacterial infections:
- Tuberculosis (TB): Pulmonary and extra-pulmonary TB (always used in combination with Isoniazid, Pyrazinamide, and Ethambutol).
- Leprosy: Multibacillary and Paucibacillary Leprosy (in combination with Dapsone/Clofazimine).
- Meningococcal Prophylaxis: Elimination of Neisseria meningitidis from the nasopharynx of asymptomatic carriers.
- Brucellosis: Combination therapy with Doxycycline.
Dosage & Administration
Recommended Dosage (Strictly as per Physician/WHO Guidelines):
- Route: Oral.
- Adults (TB): 10 mg/kg body weight, once daily. Max dose 600 mg.
- Administration (CRITICAL): Must be taken on an empty stomach (1 hour before or 2 hours after meals). Food decreases absorption by 30%.
Safety Warnings:
- Red Discoloration: Patient Counseling Point: Rifampicin will turn urine, sweat, saliva, and tears a reddish-orange color. This is harmless but can stain contact lenses and clothing permanently.
- Hepatotoxicity: Can cause liver damage. Monitor liver function tests (LFTs) regularly, especially in alcoholics.
- Enzyme Induction (Drug Interactions): Rifampicin is a potent inducer of CYP450 enzymes. It speeds up the metabolism of many other drugs (e.g., Oral Contraceptives, Warfarin, HIV meds, Anti-diabetics), making them ineffective. Dosage adjustments of other meds are mandatory.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
