Description

Orlistat Capsules (Orligal Generic)

Healthy Inc is a specialized global supplier and exporter of advanced metabolic, endocrinology, and bariatric therapeutics. We provide high-purity Orlistat Capsules (120 mg), manufactured in WHO–GMP certified, advanced oral solid dosage facilities. This “Peripheral Lipase Inhibitor” is a massive-volume, high-value export to bariatric centers, endocrinology clinics, weight-management programs, and government health ministries in the Middle East, LATAM, and Southeast Asia, serving as the definitive, globally approved pharmacological intervention for clinical obesity and weight maintenance.

Product Overview

This formulation contains Orlistat, a potent, specific, and reversible inhibitor of gastrointestinal lipases.

The “Non-Systemic Fat Blocker” Specialist:

• Mechanism (Lipase Inhibition): Orlistat exerts its therapeutic activity entirely within the lumen of the stomach and small intestine. It forms a covalent bond with the active serine residue site of gastric and pancreatic lipases. By deactivating these enzymes, it physically prevents the hydrolysis of dietary fat (triglycerides) into absorbable free fatty acids and monoglycerides.
• The Caloric Deficit Engine: At the standard therapeutic dose of 120 mg taken with meals, Orlistat blocks the digestion and absorption of approximately 30% of dietary fat. This unabsorbed fat is safely excreted intact in the feces, creating a massive, highly predictable systemic caloric deficit that drives clinical weight loss.
• Zero CNS Stimulation (The Safety Advantage): Older anti-obesity drugs (amphetamines, phentermine) cross the blood-brain barrier to suppress appetite, causing severe tachycardia, hypertension, insomnia, and chemical dependence. Orlistat has virtually zero systemic absorption. It does not affect the brain or heart, making it exceptionally safe for obese patients who already suffer from comorbid cardiovascular disease or hypertension.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule (containing advanced micro-pellets), packed in highly secure Alu-PVC or strictly high-barrier Alu-Alu blister strips to preserve the moisture-sensitive lipophilic API.

*Pack Sizes: 10×10 Alu-PVC or Alu-Alu Blisters (Optimized for 30-day or 90-day bariatric dispensing cycles).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Bariatric Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Lipophilic API Stabilization: Orlistat has an extremely low melting point (around 44°C) and is highly lipophilic, making it notoriously difficult to manufacture without the API melting or clumping into the machinery. Our facilities utilize specialized low-temperature pelletization and geometric blending to ensure the API remains perfectly stable and highly dispersible in the gastrointestinal tract.
• Dissolution Profiling: Because the drug acts entirely locally in the gut, rapid and uniform dissolution is critical. Strict in vitro testing guarantees the capsule disintegrates immediately in the stomach to mix uniformly with the patient’s dietary chyme.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of metabolic syndrome and clinical obesity:

• Obesity Management: Indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Recommended for obese patients with an initial body mass index (BMI) ≥ 30 kg/m², or ≥ 27 kg/m² in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia).
• Diabetic Weight Control: Highly utilized in Type 2 Diabetics to drive weight loss, which naturally reduces insulin resistance and improves glycemic control.

Dosage & Administration

Recommended Dosage (Strictly as per Bariatric Physician):

• Administration (TIMING IS CRITICAL): One 120 mg capsule taken with each main meal containing fat (during or up to 1 hour after the meal).
• The “Skipped Meal” Rule: If a meal is occasionally missed or contains absolutely no fat, the dose of Orlistat should be omitted, as there are no triglycerides for the drug to block.
• Mandatory Vitamin Supplementation: Because Orlistat blocks the absorption of fat-soluble vitamins (A, D, E, K, and beta-carotene), patients MUST take a daily multivitamin. This multivitamin must be taken at least 2 hours before or after the Orlistat dose (typically at bedtime).

Safety Warnings (CRITICAL):

• Gastrointestinal Effects (The “Treatment Effect”): The unabsorbed fat causes highly predictable GI events. Patients must be counseled to expect oily spotting, flatus with discharge, fecal urgency, and steatorrhea (fatty stools). These effects drastically increase if the patient consumes a meal excessively high in fat, acting as a powerful behavioral deterrent against high-fat diets.
• Severe Hepatotoxicity (Rare): Rare post-marketing cases of severe liver injury with hepatocellular necrosis or acute hepatic failure have been reported. Patients must report itching, yellow eyes/skin, or dark urine immediately.
• Renal Oxalate Stones: Orlistat can increase urinary oxalate levels. It should be used with caution in patients with a history of hyperoxaluria or calcium oxalate kidney stones.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Bariatric Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government metabolic programs in the Middle East or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.