Description
Glipizide Tablets
Healthy Inc is a specialized global supplier and exporter of rapid-acting anti-diabetic agents. We provide high-purity Glipizide Tablets (Immediate Release and Extended Release), sourced from WHO–GMP certified solid dosage facilities. This “Post-Prandial Specialist” is a top export to diabetic care clinics, government health formularies, and pharmacy chains in Africa, LATAM, and Southeast Asia, serving as a preferred Sulfonylurea for patients requiring tight control of mealtime blood sugar spikes with a lower risk of prolonged hypoglycemia compared to older agents.
Product Overview
This formulation contains Glipizide, a second-generation sulfonylurea with a rapid onset profile.
The “Mealtime” Specialist:
- Mechanism: Glipizide binds to the Sulfonylurea Receptor 1 (SUR1) on the pancreatic beta-cell membrane. This inhibits ATP-sensitive potassium channels, leading to depolarization and calcium influx, which triggers the rapid release of insulin.
- Rapid Onset (Short Acting): Unlike Glibenclamide, Glipizide is absorbed rapidly and stimulates a quick burst of insulin. This makes it exceptionally effective at controlling Post-Prandial Hyperglycemia (sugar spikes after eating).
- Renal Safety Profile: It is metabolized by the liver into inactive metabolites which are excreted in urine. This makes it safer than Glibenclamide for elderly patients or those with mild-to-moderate renal impairment, as active drugs do not accumulate in the body.
- Reduced Hypoglycemia: Its short half-life (2–4 hours) means the insulin-stimulating effect wears off relatively quickly, reducing the risk of severe, long-lasting hypoglycemia (low blood sugar) if a meal is missed later in the day.
Product Composition & Strength
We supply this product as Uncoated Tablets (Immediate Release) or Extended Release (XL/SR) Tablets using osmotic pump or matrix technology.
| Active Ingredient | Strength | Formulation | Role |
|---|---|---|---|
| Glipizide USP/BP | 5 mg | Immediate Release | Standard Initial Dose |
| Glipizide USP/BP | 10 mg | Immediate Release | High Potency Maintenance |
| Glipizide USP/BP | 5 mg / 10 mg | Extended Release (XL) | Once Daily (24hr Control) |
| Excipients | Q.S. | Lactose / Stearic Acid | Binder / Lubricant |
*Pack Sizes: Blister packs of 10s (Box of 10×10), 30s, 100s, or Bulk HDPE Jars of 500s/1000s.
Technical & Logistics Specifications
Critical data for Pharmaceutical Importers and Distributors.
| HS Code | 3004.90.99 (Other Medicaments) |
| Dosage Form | Tablet (Uncoated / XL) |
| Packaging | PVC-Alu Blister or HDPE Bottle |
| Storage | Store below 25°C. Protect from moisture and humidity. |
| Certificates | WHO-GMP, COPP, Free Sale Certificate |
Manufacturing Authority
Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.
- Dissolution Precision: For Immediate Release tablets, rapid disintegration is critical to match the post-meal glucose spike. Our formulation is engineered to release >80% of the drug within 30 minutes.
- XL Technology: For Extended Release variants, we utilize a semi-permeable membrane or hydrophilic matrix system that releases the drug at a “zero-order” rate, preventing the dumping of the dose and ensuring steady plasma levels.
Therapeutic Indications (Human Use)
Indicated for the management of Type 2 Diabetes Mellitus:
- Hyperglycemia Control: Used as an adjunct to diet and exercise to improve glycemic control.
- Patient Profile: Ideally suited for non-obese Type 2 diabetics who have significant post-prandial hyperglycemia (high sugar spikes after eating).
Dosage & Administration
Recommended Dosage (Strictly as per Endocrinologist):
- Route: Oral.
- Immediate Release (Standard):
- Initial: 5 mg daily.
- Timing (Critical): Must be taken 30 minutes BEFORE breakfast or the first main meal. Taking it *with* food delays absorption and reduces efficacy.
- Titration: Max 15 mg once daily. If higher doses (up to 40 mg) are needed, they should be divided (twice daily).
- Extended Release (XL):
- Initial: 5 mg once daily with breakfast.
- Swallow Whole: Never crush or chew XL tablets.
Safety Warnings:
- Hypoglycemia: Can cause low blood sugar, especially if the patient exercises vigorously or delays a meal after dosing.
- Weight Gain: Like all sulfonylureas, it can cause weight gain due to the anabolic effects of insulin.
- Sulfa Allergy: Contraindicated in patients with known hypersensitivity to sulfonamides.
- G6PD Deficiency: Use caution; potential for hemolytic anemia.
Global Export & Contract Manufacturing Services
Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.
Commercial Inquiries
For hospital tenders, bulk export, or distributor pricing, please contact our export team.
WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in
