Description

Estramustine Phosphate Capsules

Healthy Inc is a specialized global supplier and exporter of advanced oncology, urology, and antineoplastic therapeutics. We provide ultra-high-purity Estramustine Phosphate Capsules (140 mg), manufactured in WHO–GMP certified, dedicated negative-pressure oncology facilities with integrated cold-chain validation. This “Dual-Action Cytotoxic Alkylating Agent” is a highly specialized, premium export to comprehensive cancer centers, urology clinics, and government health ministries in LATAM, the Middle East, Southeast Asia, and Africa, serving as a definitive, life-prolonging intervention for palliative treatment of metastatic and/or progressive carcinoma of the prostate.

Product Overview

This formulation contains Estramustine Phosphate, a highly unique antineoplastic agent that chemically combines an estradiol (estrogen) molecule with a nornitrogen mustard (cytotoxic) molecule via a carbamate link.

The “Dual-Target Prostate Oncology” Specialist:

• Mechanism 1 (Targeted Antimicrotubule Cytotoxicity): Once absorbed, the drug is dephosphorylated into estramustine and estromustine. These active metabolites bind specifically to microtubule-associated proteins (MAPs) and tubulin within the prostate cancer cells. This causes the rapid disassembly of the cellular microtubule framework, completely halting cell division (mitosis) at the G2/M phase and triggering apoptosis (cell death).
• Mechanism 2 (Estrogenic Anti-Androgen Effect): Because the cytotoxic mustard is attached to an estrogen carrier, the drug exerts a profound hormonal effect. The estradiol component suppresses the release of luteinizing hormone (LH) from the pituitary gland, drastically lowering serum testosterone levels. Since prostate cancer is heavily fueled by testosterone, this chemical castration effect synergizes perfectly with the cytotoxic microtubule blockade.
• The “Carrier” Advantage: Prostate tissues possess specialized binding proteins that have a high affinity for estramustine. This allows the drug to selectively accumulate directly within the prostate tumor, delivering the cytotoxic nitrogen mustard payload exactly where it is needed while attempting to spare healthy, non-target tissues.

Product Composition & Strength

We supply this product as a Hard Gelatin Capsule, packed in highly secure, moisture-resistant Alu-Alu blister strips or heavy-gauge HDPE bottles, engineered to maintain absolute stability within strictly refrigerated environments.

*Pack Sizes: HDPE Bottles of 100 capsules / Alu-Alu Blisters (Optimized for specialized oncology dispensing).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers, Oncology Procurement Boards, and Cold-Chain Logistics Partners.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified oncology units.

• Hazardous Cytotoxic (OEB) Containment: Estramustine is a highly potent, mutagenic, and cytotoxic alkylating agent. Our manufacturing is executed within strictly isolated, completely dedicated Oncology blocks operating under severe negative pressure with multi-stage HEPA filtration. Powders are handled inside closed-loop barrier isolators to guarantee absolute operator safety and zero cross-contamination.
• Cold-Chain Validation Integration: Because the API rapidly degrades at room temperature, our encapsulation, blistering, and warehousing facilities integrate unbroken, validated cold-chain systems, ensuring the drug retains 100% of its antineoplastic potency from the factory floor to the patient.

Therapeutic Indications (Human Use)

Indicated for the comprehensive management of severe urological malignancies:

• Prostate Carcinoma: Palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate, particularly those who have become refractory to standard hormone therapy (Castration-Resistant Prostate Cancer – CRPC).

Dosage & Administration

Recommended Dosage (Strictly as per Board-Certified Urologist/Oncologist):

• Administration (DAIRY/CALCIUM WARNING IS CRITICAL): Estramustine Phosphate MUST be taken with a full glass of water on an empty stomach (at least 1 hour before or 2 hours after meals). It must NEVER be taken with milk, dairy products, or calcium/magnesium antacids. Calcium chemically binds to the phosphate component of the drug in the gut, completely destroying its absorption and rendering the chemotherapy useless.
• Handling Precautions (HAZARD WARNING): Capsules must be swallowed whole. They MUST NOT be opened, broken, or chewed. Estramustine is a hazardous cytotoxic drug. Healthcare providers, patients, and caregivers must wear gloves when handling the capsules.

Safety Warnings (CRITICAL):

• BLACK BOX WARNING EQUIVALENT (Severe Thromboembolism): Because Estramustine contains a potent estrogen component, it massively increases the risk of fatal cardiovascular events, including Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), and Myocardial Infarction. It must be used with extreme caution in patients with a history of thrombophlebitis or coronary artery disease.
• Hepatotoxicity & Fluid Retention: May cause significant elevations in bilirubin and liver enzymes. The estrogenic effect also causes severe fluid retention, which can exacerbate congestive heart failure, asthma, or epilepsy.
• Gynecomastia & Impotence: Profound estrogenic side effects are universally expected, including severe breast tenderness, gynecomastia (enlargement of breast tissue), and total impotence.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Advanced Oncology and Urological Formulations, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government prostate cancer programs in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely cold-chain delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Specialty Medicine Wholesaler receives WHO-GMP certified products at competitive rates.