Metformin SR + Glimepiride: The “Dual-Action” Standard for Type 2 Diabetes Management

Introduction: Why “Two in One” is Better Managing Type 2 Diabetes is a 24-hour challenge. For millions of patients in Africa, Latin America, and Southeast Asia, the struggle isn’t just high blood sugar—it’s the burden of taking multiple pills every day.

At Healthy Inc, we specialize in the advanced manufacturing of Metformin Hydrochloride (SR) & Glimepiride Fixed-Dose Combinations (FDCs). Whether you are a patient looking to understand your therapy or a pharmaceutical distributor seeking a WHO-GMP certified partner, this guide explains why this combination is the global “Gold Standard” for chronic care.

1. For Patients: Understanding the “Dual-Action” Power

This combination attacks diabetes from two distinct angles, offering superior glycemic control compared to monotherapy:

• The Sensitizer (Metformin): It decreases glucose production in the liver and makes the body’s muscles more sensitive to insulin.

• The Booster (Glimepiride): As a 3rd Generation Sulfonylurea, it signals your pancreas to release more insulin to handle mealtime sugar spikes.

Why is this better than single tablets?

• Reduced “Pill Burden”: Taking one tablet instead of two improves adherence.

• Sustained Control: Our Sustained Release (SR) technology ensures the medicine works over 24 hours, preventing dangerous highs and lows.

• Heart Health: Glimepiride is selective for pancreatic receptors, preserving the heart’s ischemic preconditioning response better than older drugs like Glibenclamide.

2. Important Usage & Safety Information

Medical Disclaimer: Always consult your physician for dosage instructions.

• Best Time to Take: Usually taken once daily with breakfast or the first main meal.

• Do Not Crush: Because this is an “SR” (Sustained Release) tablet, crushing it breaks the matrix and releases the drug too fast.

• Hypoglycemia Warning: Since Glimepiride increases insulin, skipping meals can cause low blood sugar. Always carry a quick source of sugar.

• Alcohol Warning: Avoid excessive alcohol as it increases the risk of both hypoglycemia and lactic acidosis.

3. The Manufacturing Science: Why “Bilayer” Matters

Target Audience: Pharmacists & Importers

Producing a stable FDC is a complex engineering challenge. Metformin is hygroscopic (absorbs moisture), while Glimepiride is potent in micro-doses. Mixing them carelessly can lead to instability.

The Healthy Inc Difference: We utilize Bilayer Compression Technology to physically separate the two Active Pharmaceutical Ingredients (APIs) within a single tablet.

• Layer 1 (Glimepiride): Formulated for immediate release to handle post-meal spikes.

• Layer 2 (Metformin SR): A hydrophilic matrix that releases the drug slowly over 10-12 hours to reduce gastrointestinal side effects.

This separation ensures Chemical Stability in high-humidity climates (Zone IVb), making our product ideal for export to tropical regions.

4. Commercial & Logistics Data for Importers

For our B2B partners, we offer a “Pharmacy-Ready” product with complete documentation.

• HS Code: 3004.90.99 (Other Medicaments)

• Packaging: Alu-Alu Blister packs (Moisture Barrier) to ensure 2-3 year shelf life.

• Available Strengths:

  • G1: Metformin 500mg + Glimepiride 1mg

  • G2: Metformin 500mg + Glimepiride 2mg

  • Forte: Metformin 1000mg + Glimepiride 2mg

• Certifications: WHO-GMP, COPP, Free Sale Certificate (FSC).

• Services: Third Party Manufacturing (Contract Manufacturing) and Hospital Tender Supply.

[Click here to view full Product Specifications & COA]

Frequently Asked Questions (FAQ)

Q: What is the advantage of the Bilayer tablet over a normal tablet? A: Bilayer tablets physically separate the Metformin and Glimepiride. This prevents chemical interaction between the ingredients, ensuring the medicine remains effective for its entire shelf life, especially in hot and humid climates.

Q: Can this tablet cause weight gain? A: Glimepiride can cause mild weight gain in some patients. However, Metformin helps counteract this by improving metabolism. A balanced diet is essential.

Q: Do you export to Africa and LATAM? A: Yes, Healthy Inc acts as a specialized Pharmaceutical Exporter to these regions. We provide full dossier support and assist with shipping logistics for bulk orders.

Q: Is this product WHO-GMP certified? A: Yes, all our Metformin + Glimepiride formulations are manufactured in WHO-GMP certified facilities in India, ensuring global quality standards.

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