Healthy Inc > Products > Pyrimethamine Sulphadoxine Tablets

Pyrimethamine and Sulphadoxine Tablets

Healthy Inc is a specialized global supplier and exporter of essential antimalarial combination therapies (ACTs) and SP formulations. We provide high-purity Pyrimethamine and Sulphadoxine Tablets, sourced from WHO–GMP certified solid dosage facilities. This “Synergistic” Antimalarial is a top export to National Malaria Control Programs (NMCP), maternal health clinics, and government tenders in Africa (sub-Saharan), LATAM, and Southeast Asia, recognized as the “Gold Standard” for Intermittent Preventive Treatment in pregnancy (IPTp) and the treatment of uncomplicated malaria.

Product Overview

This formulation contains a fixed-dose combination of Sulphadoxine (a long-acting sulfonamide) and Pyrimethamine (a diaminopyrimidine).

The “Double Blockade” Specialist:

  • Synergy (1+1=10): Both drugs attack the malaria parasite’s folic acid synthesis pathway, but at different steps.
    • Sulphadoxine inhibits the enzyme dihydropteroate synthase (blocking synthesis).
    • Pyrimethamine inhibits the enzyme dihydrofolate reductase (blocking activation).
  • Sequential Blockade: By blocking the pathway at two consecutive points, the combination is super-additive (bactericidal/parasiticidal), killing the parasite much more effectively than either drug could alone.
  • IPTp Role: Because both drugs have very long half-lives, a single dose provides protection for weeks. This makes it the drug of choice for Intermittent Preventive Treatment in pregnancy (IPTp), significantly reducing low birth weight and maternal anemia in endemic zones.

Product Composition & Strength

We supply this product as Uncoated Tablets (White to Off-white, scored). The 500/25 ratio is the global therapeutic standard.

Active IngredientStrength (Standard)Primary Role
Sulphadoxine USP/BP500 mgFolate Synthesis Inhibitor
Pyrimethamine USP/BP25 mgFolate Reductase Inhibitor
ExcipientsQ.S.Corn Starch / Gelatin / Magnesium Stearate

*Pack Sizes: Blister packs of 3s (Single Treatment Dose), Box of 10×3, 50×3, or Bulk HDPE Jars of 1000s (Clinic Packs).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

HS Code3004.60.00 (Medicaments containing antimalarial principles)
Dosage FormTablet (Oral)
PackagingPVC-Alu Blister or Alu-Alu Blister
StorageStore below 30°C. Protect from light.
CertificatesWHO-GMP, COPP, Free Sale Certificate

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

  • Dissolution Efficacy: Resistance to SP (Sulphadoxine-Pyrimethamine) is a concern in some regions. Our formulation is engineered for rapid dissolution (>85% in 30 mins) to ensure high peak serum concentrations, which is critical for overcoming parasites with low-level resistance mutations.
  • Sulfa Purity: We utilize high-grade Sulphadoxine with strictly controlled levels of aniline impurities to minimize the risk of allergic reactions.

Therapeutic Indications (Human Use)

Indicated for the treatment and prevention of malaria:

  • Treatment: Acute, uncomplicated P. falciparum malaria (often used where Chloroquine resistance is present).
  • IPTp (Pregnancy): Administration of a full therapeutic course of SP to pregnant women at scheduled antenatal care visits (after the first trimester) to prevent “Placental Malaria.”
  • IPTi (Infants): Intermittent preventive treatment in infants (in specific WHO-designated zones).

Dosage & Administration

Recommended Dosage (Strictly as per WHO/National Guidelines):

  • Route: Oral.
  • Treatment (Adults > 45kg): Single dose of 3 tablets taken all at once.
  • IPTp (Pregnant Women): 3 tablets taken as a single dose. Administered at least 3 times during pregnancy (starting in 2nd trimester), with at least 1 month between doses.
  • Children:
    • 5-10 kg: 1/2 tablet.
    • 11-20 kg: 1 tablet.
    • 21-45 kg: 2 tablets.
  • Administration: Take with plenty of water.

Safety Warnings:

  • Sulfa Allergy (CRITICAL): Contraindicated in patients with known hypersensitivity to sulfonamides. Can cause life-threatening Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN). Stop immediately if a rash appears.
  • G6PD Deficiency: Can cause severe hemolysis (anemia) in patients with G6PD deficiency.
  • Infants: Contraindicated in infants under 2 months of age (risk of kernicterus).
  • Folic Acid Supplements: High doses of folic acid (≥5 mg) should not be taken concomitantly as they antagonize the drug’s effect. (0.4mg standard prenatal dose is usually acceptable).

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for OSD (Oral Solid Dosage) forms, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.

Commercial Inquiries

For hospital tenders, bulk export, or distributor pricing, please contact our export team.

WhatsApp/Call: +91 7710003340
Email: info@healthyinc.co.in

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