Acitretin Film-Coated Tablets (10 mg / 25 mg)

Healthy Inc is a specialized global supplier and exporter of advanced dermatology, immunology, and targeted high-containment therapeutics. We provide ultra-high-purity, kinetically optimized Acitretin Tablets, manufactured in WHO–GMP certified, high-precision specialized oral solid dosage facilities. This “Second-Generation Retinoid” is a premium strategic export to dermatology hospitals, psoriasis centers, and government health ministries, serving as the globally mandated intervention for Severe Psoriasis and Keratinization Disorders.

Product Overview

This formulation operates as a “Genetic Skin Regulator.” Acitretin is a metabolite of Etretinate; it works by entering the nucleus of skin cells and changing how they grow and shed.

• Mechanism 1 (Nuclear Receptor Binding): Acitretin binds to specific Retinoic Acid Receptors (RARs) inside the skin cells. This binding acts as a “command signal” to the cell’s DNA.

• Mechanism 2 (Normalization of Proliferation): In Psoriasis, skin cells multiply too fast. Acitretin physically slows down this overactive growth and promotes normal cell differentiation, preventing the formation of thick, scaly plaques.

• Mechanism 3 (Anti-Inflammatory Action): It reduces the infiltration of inflammatory cells into the skin, significantly decreasing redness and irritation associated with erythrodermic and pustular psoriasis.

Product Composition & Strength

We supply this product in standardized strengths to allow for precise clinical titration, packed in high-barrier Alu-Alu blister strips.

Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments containing other active substances – Dermatology)

• CAS Number: 55079-83-9 (Acitretin)

• Dosage Form: Film-Coated Tablet / Capsule

• Packaging: Alu-Alu Blisters. Acitretin is highly sensitive to light and moisture; our moisture-lock packaging ensures 24-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Retinoid Purity Excellence: Our manufacturing process focuses on absolute chemical stability to prevent the “reverse metabolism” of Acitretin back into Etretinate, ensuring the predictable half-life required for patient safety.

• Specialized Containment: We utilize Dedicated Retinoid Production Blocks to ensure zero cross-contamination, meeting the strictest international regulatory standards for specialized dermatological medications.

Primary Indications

• Dermatology: Severe Psoriasis (including erythrodermic and localized or generalized pustular types).

• Genodermatoses: Severe disorders of keratinization such as Ichthyosis, Darier’s disease, and Pityriasis Rubra Pilaris (PRP).

• Specialist Care: Management of skin conditions that are resistant to other systemic therapies or PUVA.

Dosage & Administration

• Standard Adult Dosing: Initially 25 mg to 30 mg once daily for 2 to 4 weeks, followed by a maintenance dose based on clinical response.

• Administration: Must be taken with a main meal or with milk to ensure maximum absorption.

Safety Warning: Severe Teratogenicity. Acitretin causes severe birth defects. MANDATORY: Females of reproductive potential must use two forms of effective contraception and avoid pregnancy for 3 years after stopping the drug. Alcohol Restriction: Alcohol must be avoided during and for 2 months after therapy, as it can convert Acitretin into the long-lasting Etretinate. Monitor Liver Function Tests (LFTs) and lipid profiles regularly.

Global Export & Contract Manufacturing

Healthy Inc is a premier Dermatology Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for specialized Systemic Retinoids. Whether you are a Dermatology Hospital Network in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.