Description

Cefepime & Sulbactam Injection

Healthy Inc is a specialized global supplier and exporter of high-stability antibiotic combinations. We provide high-purity Cefepime & Sulbactam Injection (1.5 g), sourced from WHO–GMP certified sterile injectable facilities. This “Broad-Spectrum Shield” is a top export to neurosurgery wards, intensive care units (ICU), and government health ministries in Africa, LATAM, and Southeast Asia, serving as a critical empirical therapy for MDR *Acinetobacter* and *Pseudomonas* infections.

Product Overview

This formulation combines Cefepime, a fourth-generation zwitterionic cephalosporin, with Sulbactam, a beta-lactamase inhibitor.

The “Neuro-Safe” Specialist:

• Synergy (The “Acinetobacter” Killer): While Cefepime covers *Pseudomonas* and *Enterobacter*, it is vulnerable to some beta-lactamases. Sulbactam not only inhibits these enzymes but also possesses intrinsic antibacterial activity against *Acinetobacter baumannii*. This makes the combination a powerful weapon against ventilator-associated pneumonia (VAP) in ICUs.
• Zwitterionic Speed: Cefepime’s dipolar nature allows it to penetrate the outer membrane of Gram-negative bacteria rapidly, evading efflux pumps better than older cephalosporins.
• CNS Penetration: Both Cefepime and Sulbactam cross the blood-brain barrier well when meninges are inflamed, making this combination useful for treating post-neurosurgical meningitis caused by resistant organisms.

Product Composition & Strength

We supply this product as a Sterile Dry Powder for Injection in glass vials. The standard ratio is 2:1.

*Pack Sizes: Tray of 1 Vial, 10 Vials, or Box of 1/10 Vials with Water for Injection (WFI).

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Arginine Buffering: We use L-Arginine to buffer the Cefepime component. This improves solubility and reduces the sodium load compared to traditional sodium carbonate buffers, which is beneficial for ICU patients with fluid restrictions.
• Hygroscopicity Management: Sulbactam is extremely sensitive to moisture. Our manufacturing process uses ultra-low humidity isolators (< 20% RH) to ensure the powder remains free-flowing and does not cake, guaranteeing rapid reconstitution.

Therapeutic Indications (Human Use)

Indicated for the treatment of severe, life-threatening infections:

• Nosocomial Meningitis: Post-surgical meningitis caused by resistant Gram-negatives.
• Ventilator-Associated Pneumonia (VAP): Particularly when *Acinetobacter* or *Pseudomonas* is suspected.
• Febrile Neutropenia: Empirical therapy for immunocompromised cancer patients.
• Complicated Intra-abdominal Infections: Peritonitis (covers anaerobes).
• Severe UTIs: Pyelonephritis caused by MDR *E. coli*.

Dosage & Administration

Recommended Dosage (Strictly as per Physician):

• Route: Intravenous (IV) Infusion Preferred. (Can be given Deep IM).
• Adults: 1.5 g to 3 g every 12 hours.
• Severe Infections / Meningitis: 3 g every 8 hours.
• Renal Impairment (CRITICAL): Dose adjustment is mandatory if Creatinine Clearance < 50 ml/min. Both drugs accumulate in renal failure.
• Reconstitution: Dissolve 1.5g vial in 10-20ml WFI/Saline. Solution turns pale yellow to amber.

Safety Warnings (CRITICAL):

• Neurotoxicity (Encephalopathy): Accumulation of Cefepime in renal failure patients can cause confusion, myoclonus, and seizures. Monitor renal function daily.
• Penicillin Allergy: CONTRAINDICATED in patients with a history of anaphylaxis to beta-lactams.
• Superinfection: Prolonged use may result in fungal or *Clostridium difficile* overgrowth.

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.