Yes, Ketorol (brand name for Ketorolac Tromethamine) is one of the most powerful non-narcotic analgesics used in dentistry for acute, severe pain. In our pharmaceutical context, we classify it as an NSAID with efficacy comparable to low-dose morphine, but without the opioid side effects.
Clinical Application in Dentistry
Ketorol is specifically indicated for the short-term management (up to 5 days) of moderate to severe acute pain. It is highly effective for:
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Post-Extraction Pain: Especially after surgical removal of impacted wisdom teeth.
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Acute Pulpitis: Intense pain caused by inflammation of the dental pulp.
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Dental Abscesses: Reducing the severe inflammation and throbbing pain associated with infections.
Mechanism of Action
Ketorol works by potent inhibition of the COX-1 and COX-2 enzymes.
Prostaglandin Blockade: It stops the synthesis of prostaglandins at the site of the tooth and jaw, which are the primary mediators of pain and swelling.
Peripheral Action: Unlike central analgesics, it works directly at the site of the dental injury/inflammation.
The Manufacturer’s Perspective: Technical & Export Details
As you are looking to promote your firm and develop your digital platforms, here is how we position Ketorolac in the B2B and export market:
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Dosage Forms: We manufacture Ketorol in 10 mg tablets and 30 mg/ml injections. For the dental market, the DT (Dispersible Tablet) version is highly popular as it allows for faster absorption and is easier for patients with jaw stiffness (trismus) to take.
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The “5-Day Rule”: Because of its high potency, Ketorol has a strict regulatory requirement in the eCTD Dossier and Product Information Leaflet (PIL) stating it must not be used for more than 5 days. This prevents serious renal (kidney) and GI (gastric) side effects.
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Stability & Packaging: Ketorolac is sensitive to light. At our WHO-GMP facility in Mumbai, we utilize Amber-colored PVC or Alu-Alu blister packaging to ensure a 24-36 month shelf life for export to Zone IVb regions.
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Market Synergy: In your multivendor marketplace, Ketorolac is often bundled with antibiotics like Amoxicillin + Clavulanate for complete dental procedure kits.