Thioguanine Tablets

Product Composition & Strength

We supply this product in the globally standardized 40 mg strength, optimized for adult and pediatric weight-based dosing.

Active Ingredient	Strength	Primary Clinical Function
Thioguanine USP/Ph.Eur.	40 mg	The DNA Saboteur: Mimics guanine to stop the replication of leukemic cells.
Excipients	Pharmaceutical Grade	Stability Matrix: Engineered to protect the sensitive API from environmental degradation.

Thioguanine Tablets

Healthy Inc is a specialized global supplier and exporter of advanced oncology, hematology, and targeted high-containment therapeutics. We provide ultra-high-purity, kinetically optimized Thioguanine Tablets, manufactured in WHO–GMP certified, strictly segregated high-containment oncology facilities. This "Guanine Analogue" is a premium strategic export to hematology hospitals, specialized cancer centers, and government health ministries, serving as a globally mandated intervention for the treatment of Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL).

Product Overview

This formulation operates as a "Genetic Fraud." Thioguanine is a pro-drug that mimics the natural building blocks of DNA, physically tricking the cancer cell into its own destruction.

• Mechanism 1 (Purine Antagonism): Thioguanine is an analogue of the natural purine base Guanine. Once inside the body, it is converted into thioguanine nucleotides.

• Mechanism 2 (DNA Incorporation & Fraud): The leukemic cell mistakenly incorporates these "fake" nucleotides into its DNA and RNA strands during replication.

• Mechanism 3 (Cytotoxicity & Apoptosis): Once the fake building blocks are in place, the DNA chain becomes unstable and cannot function. This physically triggers Apoptosis (programmed cell death) in the fast-multiplying cancer cells.

 Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments containing other active substances - Oncology/Antimetabolites)

• CAS Number: 154-42-7 (Thioguanine)

• Dosage Form: Uncoated or Film-Coated Tablet

• Packaging: Alu-Alu Blisters or Glass Bottles. Thioguanine is sensitive to light and moisture; our high-barrier packaging ensures 24-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• OEB 5 High-Containment: Thioguanine is a potent cytotoxic agent. Our facility utilizes Dedicated Oncology Blocks with negative pressure and isolator technology to ensure zero cross-contamination.

• Hematologic Precision: Our manufacturing process focuses on absolute chemical purity, ensuring the Purine Analogue remains stable and provides the predictable myelosuppressive response required for leukemia protocols.

Primary Indications

• Hematology: Remission induction and maintenance therapy in Acute Myeloid Leukemia (AML).

• Oncology: Treatment of Acute Lymphoblastic Leukemia (ALL) and Chronic Myeloid Leukemia (CML).

• Specialist Care: Occasionally used in the management of severe inflammatory bowel disease (IBD) under strict specialist supervision.

Dosage & Administration

• Standard Adult/Pediatric Dosing: Usually calculated based on body surface area (e.g., 75–100 $mg/m^2$ daily).

• Administration: Can be taken with or without food, but consistency is key.

• Important: Dose adjustments are critical based on blood counts and the presence of TPMT (Thiopurine S-methyltransferase) enzyme deficiency.

Safety Warning: Bone Marrow Suppression. Thioguanine causes significant drops in white blood cells and platelets. MANDATORY: Frequent Full Blood Counts (FBC) are required. Hepatotoxicity: Monitor Liver Function Tests (LFTs) for signs of Veno-Occlusive Disease (VOD). Use with extreme caution in patients with a known TPMT deficiency, as they are at high risk for life-threatening toxicity.

Global Export & Contract Manufacturing

Healthy Inc is a premier Oncology and Hematology Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for high-containment antimetabolites. Whether you are a National Cancer Institute in Africa or a B2B Pharma Marketplace partner in the CIS, we ensure secure, WHO-GMP compliant delivery.

https://healthyinc.co.in/product/thioguanine-6-tg-40-mg-tab/