Description

Neostigmine Methylsulfate Injection

Healthy Inc is a specialized global supplier and exporter of high-purity cholinergic agents. We provide Neostigmine Methylsulfate Injection (0.5 mg / ml), manufactured in WHO–GMP certified sterile facilities. This “Anesthesia Reversal” agent is a mandatory export to surgical theaters, recovery rooms, and government health ministries in Africa, LATAM, and Southeast Asia, serving as the gold standard for reversing the effects of non-depolarizing muscle relaxants after surgery and managing Myasthenia Gravis.

Product Overview

This formulation contains Neostigmine Methylsulfate, a synthetic quaternary ammonium compound that acts as a reversible anticholinesterase agent.

The “Transmission Restorer” Specialist:

• Mechanism (The Enzyme Blocker): Neostigmine inhibits the enzyme Acetylcholinesterase, which is responsible for breaking down Acetylcholine (ACh). By stopping this breakdown, it allows ACh to accumulate at the neuromuscular junction (NMJ).
• Anesthesia Reversal: In surgery, muscle relaxants (like Rocuronium or Vecuronium) block the NMJ to paralyze muscles. Neostigmine floods the junction with ACh, displacing the relaxant and restoring muscle strength so the patient can breathe on their own again.
• Myasthenia Gravis: It improves muscle tone in patients with this autoimmune disease by ensuring maximum utilization of the few available acetylcholine receptors.

Product Composition & Strength

We supply this product as a Sterile Isotonic Solution in glass ampoules or vials.

*Pack Sizes: Tray of 10 Ampoules or Box of 1/10 Vials.

Technical & Logistics Specifications

Critical data for Pharmaceutical Importers and Distributors.

Manufacturing Authority

Marketed and Distributed by Healthy Inc from WHO-GMP & ISO 9001:2015 certified units.

• Hydrolysis Protection: Neostigmine is sensitive to hydrolysis in alkaline conditions. Our formulation is strictly buffered to a pH range of 5.0–6.5 to ensure the ester bond remains intact throughout the shelf life.
• Sterility Assurance: Since it is often administered during the critical recovery phase of anesthesia, we use aseptic filling lines to guarantee a sterile, particle-free solution.

Therapeutic Indications (Human Use)

Indicated for the restoration of muscle function and tone:

• Reversal of NMBAs: Reversal of non-depolarizing neuromuscular blocking agents (Rocuronium, Vecuronium, Atracurium) after surgery.
• Myasthenia Gravis: Symptomatic treatment to improve muscle strength.
• Urinary Retention: Prevention and treatment of post-operative urinary distention/retention.
• Paralytic Ileus: To stimulate gastric motility after surgery.

Dosage & Administration

Recommended Dosage (Strictly as per Anesthesiologist):

• Route: Intravenous (IV), Intramuscular (IM), or Subcutaneous (SC).
• Reversal of Anesthesia (IV): 0.03 mg/kg to 0.07 mg/kg.
  • CRITICAL CO-ADMINISTRATION: Neostigmine causes severe bradycardia (slow heart rate). It MUST be administered with an anticholinergic like Atropine (0.6–1.2 mg) or Glycopyrrolate (0.2–0.6 mg) to prevent cardiac arrest.
• Myasthenia Gravis: 0.5 mg to 2.5 mg IM/SC every 1-3 hours depending on response.

Safety Warnings (CRITICAL):

• Bradycardia/Cardiac Arrest: As noted above, never give IV Neostigmine without Atropine/Glycopyrrolate unless the patient is already tachycardic.
• Bronchoconstriction: Increases bronchial secretions and constriction. Use with caution in asthmatics.
• Mechanical Obstruction: CONTRAINDICATED in patients with mechanical intestinal or urinary obstruction (can cause rupture).

Global Export & Contract Manufacturing Services

Healthy Inc stands as a premier Pharmaceutical Exporter in India, dedicated to serving the needs of international Pharma Traders, Wholesalers, and Bulk Drug Distributors. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) services for Sterile Injectables, allowing brands to launch high-quality generic medicines under their own label. Whether you are looking for a reliable Hospital Tender Supplier for government procurement in Africa or a B2B Pharma Marketplace partner for Latin America, our logistics network ensures timely delivery. We actively support Pharmaceutical Drop Shipping models and bulk indenting, ensuring that every Generic Medicine Wholesaler receives WHO-GMP certified products at competitive rates.