Description

Cyproheptadine Tablets

Cyproheptadine Hydrochloride Tablets USP / BP / IP (4 mg)

Tricyclic H1-Antihistamine & Potent Anti-Serotonergic Orexigenic Agent

Healthy Life Pharma Private Limited, alongside our specialized global export and marketing division Healthy Inc, is a leading Indian manufacturer, CDMO services provider, and wholesale exporter of advanced respiratory, allergy, gastroenterology, and metabolic health therapeutics. We manufacture ultra-high-purity, chemically stable Cyproheptadine Hydrochloride Tablets inside our state-of-the-art, WHO–GMP certified, high-capacity solid dosage manufacturing complexes.

Serving as a unique multi-indication therapeutic milestone for both allergy suppression and pathological weight-loss reversal, this essential product represents a high-velocity strategic export to pediatric care networks, institutional procurement lines, national health ministry tenders, and digital B2B marketplaces across Sub-Saharan Africa, the CIS region, LATAM, and South-East Asia.

Product Overview

This formulation operates as a “Dual-Pathway Histaminergic & Serotonergic Receptor Deactivator.” It ensures immediate allergy relief and stimulates physiological appetite pathways by selectively blocking the specific chemical docks that signal tissue inflammation and metabolic fullness.

• Mechanism 1 (Selective H1-Receptor Antagonism): Cyproheptadine physically attaches to and competitively blocks peripheral histamine H1 receptors on vascular smooth muscle, endothelial cells, and bronchial tracts. This shuts down the capillary leakage, tissue swelling, and mucus hypersecretion that drive sneezing, rhinorrhea, and pruritus.

• Mechanism 2 (Central 5-HT2 Receptor Blockade): Concurrently, it crosses the blood-brain barrier and acts as a powerful antagonist at serotonin 5-HT2 receptors located within the appetite control centers of the hypothalamus.

• Mechanism 3 (Hypothalamic Appetite Stimulation): Serotonin binding at 5-HT2 receptors normally signals satiety (the feeling of full fullness) to turn off appetite. By physically blocking this serotonergic trigger, Cyproheptadine suppresses fullness signals and directly activates orexigenic (appetite-stimulating) pathways, boosting caloric drive and weight gain.

Product Composition & Configuration

We supply Cyproheptadine Hydrochloride in the globally standardized 4 mg therapeutic dosage configuration, engineered to optimize absorption kinetics and support highly flexible pediatric-to-adult dose fractioning.

Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments acting on the nervous/respiratory system / Antihistamines)

• CAS Number: 41354-29-4 (Cyproheptadine Hydrochloride Sesquihydrate) / 968-81-0 (Cyproheptadine Base)

• Dosage Form: Oral Solid Tablet (Engineered as a compact, flat-faced tablet with a deep-set center score line for exact half-dose fractioning down to 2 mg)

• Packaging Configurations:

  • Retail Blisters: 10 / 14 / 20 / 30 Tablets per Blister Strip packed in high-barrier Alu-Alu (Cold-Form Foil) or silver PVC/PVDC strips.

  • Institutional Tenders: Bulk packs of 100 / 500 / 1000 Tablets per induction-sealed HDPE Bottle to maximize shipping cube efficiency and lower unit freight costs for national public health ministries. Our premium tropicalized packaging completely shields the active tricyclic core from moisture and heat transit, guaranteeing a full 36-month shelf life in hot, humid Zone IVb export environments.

Advanced Manufacturing Integrity & Quality Controls

• High-Velocity Multi-Million Unit Output: To effortlessly satisfy heavy volume institutional procurement demands and seasonal tender deadlines, we operate automated, high-output rotary tableting lines equipped with Forced-Feeder Die Matrix Modules and Online Multi-Point Weight Verifiers, physically ensuring flawless mass uniformity across massive continuous runs.

• Low Moisture Fluid-Bed Granulation: Cyproheptadine active powder requires exceptionally uniform matrix distribution to prevent compression capping. We process our blending, wet granulation, and drying cycles within Climate-Controlled Processing Blocks with relative humidity strictly held below 40%, preserving core physical stability.

• Rapid Disintegration Kinetics Verification: Every single production batch physically undergoes automated multi-pH dissolution profiling, chemically validating that our generic tablets achieve immediate disintegration (under 5 minutes), ensuring rapid gastric release and precise bioequivalence to match global innovator references (such as Periactin).

Primary Indications

• Metabolic Adjuvant & Nutrition: Stimulation of appetite and reversal of severe weight loss in patients presenting with Cachexia, Anorexia Nervosa, Failure to Thrive, or post-illness metabolic depletion.

• Allergy & Respiratory Care: Symptomatic relief of perennial and seasonal Allergic Rhinitis, vasomotor rhinitis, allergic conjunctivitis, and acute manifestations of Chronic Idiopathic Urticaria (hives).

• Dermatology: Alleviation of intense localized pruritus (itching) associated with dermographism, eczematoid dermatitis, and drug-induced allergic rashes.

• Neurology Adjuvant: Off-label carefully monitored prophylaxis of vascular headaches and severe Migraines (due to its anti-serotonergic vasoconstrictive actions).

Usage Instructions

• The Dose Fractioning Titration Matrix: Take the tablet orally with a full glass of water. It can be administered consistently either with or without food. When utilized for appetite stimulation, it is clinically recommended to administer the dose 20 to 30 minutes before principal meals.

• The Sedation Nighttime Offset: Cyproheptadine possesses strong central antihistaminergic effects, which can cause significant daytime drowsiness during the initial 48 hours of therapy. Advise pharmacy networks that initiating titration with a single evening dose at bedtime helps build systemic tolerance while avoiding daytime motor slowing.

• Serotonin Syndrome Emergency Rescue Note: Because Cyproheptadine is an exceptionally potent 5-HT2 receptor antagonist, it is used off-label as a critical antidote for the medical management of severe Serotonin Syndrome caused by the toxic accumulation of selective serotonin reuptake inhibitors (SSRIs) or MAOIs.

Safety Warning: POTENT FIRST-GENERATION ANTIHISTAMINE & ANTI-SEROTONERGIC. For Professional Medical and Specialty Dosing Guidelines Only. Sedation Safety Alert: May induce significant daytime drowsiness or psychomotor slowing; advise patients against operating heavy industrial automated machinery or driving motor vehicles until tolerance is established. Anticholinergic Toxicity Matrix: Exhibits moderate secondary anticholinergic properties; use with caution in patients presenting with prostatic hypertrophy, urinary retention, or chronic narrow-angle glaucoma. Absolute Contraindications: Absolute contraindications in newborn or premature infants, lactating mothers, elderly debilitated profiles presenting with severe urinary retention, concurrent use of monoamine oxidase inhibitors (MAOIs), or known hypersensitivity to cyproheptadine tricyclic matrices.

Global CDMO Services & Wholesale Tender Logistics

Healthy Life Pharma Private Limited and Healthy Inc provide comprehensive, internationally validated Third-Party Contract Manufacturing (CDMO Services) and bulk private-label export pipelines for the entire Cyproheptadine Hydrochloride portfolio. Because this molecule faces zero controlled-substance dual-licensing hurdles, our high-capacity lines can rapidly manufacture, release, and ship multi-container shipping loads. We handle all mandatory documentation (WHO-GMP Certificate, Certificates of Pharmaceutical Product – COPP, Certificates of Analysis – COA, Stability Testing Matrix Sheets, and Complete CTD Format Dossier sets) for seamless entry registration.

Commercial & Bulk Procurement Inquiries:

• Corporate Head Office: Mumbai, Maharashtra, India

• Primary Manufacturing Base: Boisar, Maharashtra, India

• WhatsApp / Direct Call: +91 7710003340

• Corporate Email: info@healthyinc.co.in