Description

Betahistine Tablets 

Healthy Inc is a specialized global supplier and exporter of advanced ENT, neurology, and targeted vestibular therapeutics. We provide ultra-high-purity, kinetically optimized Betahistine Tablets, manufactured in WHO–GMP certified, high-precision oral solid dosage facilities. This “Histamine Analogue & Vasodilator” is a massive-volume strategic export to ENT hospitals, audiology clinics, and government health ministries, serving as the globally mandated intervention for Meniere’s Disease, Tinnitus, and Vestibular Vertigo.

Product Overview

This formulation operates as a specialized “Circulation Booster” for the delicate structures of the inner ear. Betahistine works by mimicking the positive effects of histamine without the typical systemic allergy side effects, specifically targeting the vessels that supply the vestibular system.

• Mechanism 1 (H1-Receptor Agonism): Betahistine acts as a weak agonist at $H_1$ receptors in the inner ear. This triggers a potent local vasodilation, increasing blood flow to the Stria Vascularis, which helps regulate the pressure of the endolymphatic fluid.

• Mechanism 2 (H3-Receptor Antagonism): It acts as a powerful antagonist at pre-synaptic $H_3$ receptors. This increases the release of natural histamine and other neurotransmitters in the vestibular nuclei of the brain, accelerating Vestibular Compensation (the brain’s ability to “re-calibrate” after a dizzy spell).

• Mechanism 3 (The Endolymphatic Pressure Relief): By improving microcirculation and permeability, it reduces the buildup of excess fluid (endolymphatic hydrops) in the cochlea, which is the primary cause of the “Fullness,” vertigo, and hearing loss in Meniere’s patients.

Technical & Logistics Specifications

• HS Code: 3004.90.99 (Medicaments containing other active substances – ENT/Neuro)

• CAS Number: 5638-76-6 (Betahistine) / 5579-84-0 (Betahistine Dihydrochloride)

• Dosage Form: Uncoated or Film-Coated Tablet

• Packaging: Alu-Alu Blisters (MANDATORY). Betahistine Dihydrochloride is highly hygroscopic (absorbs moisture); our moisture-lock packaging ensures 24-month stability in Zone IVb tropical climates.

Manufacturing Authority & Compliance

• Microcirculation Precision: Our manufacturing process focuses on absolute chemical stability to ensure the Dihydrochloride salt remains potent, providing the consistent $H_3$ antagonism required for neuro-vestibular recovery.

• Content Uniformity: We utilize Advanced High-Shear Mixing to ensure every tablet in a mass-production batch provides the exact clinical dose, critical for patients sensitive to vestibular fluctuations.

Primary Indications

• ENT/Audiology: Treatment of Meniere’s syndrome (Vertigo, Tinnitus, and Hearing Loss).

• Neurology: Symptomatic treatment of vestibular vertigo of various origins.

• Supportive Care: Management of “ringing in the ears” (Tinnitus) associated with vascular disorders.

Dosage & Administration

• Standard Adult Dosing: 24 mg to 48 mg per day, usually divided into three doses (e.g., 8 mg TID or 16 mg TID).

• The “Full Stomach” Advantage: Betahistine should be taken with or after meals to reduce the risk of mild stomach upset.

• Duration: Clinical improvement may take several weeks; steady-state concentration is key for long-term relief.

Safety Warning: Use with caution in patients with Pheochromocytoma or active Peptic Ulcers. Monitor patients with bronchial asthma closely, as histamine analogues can theoretically cause bronchospasm.

Global Export & Contract Manufacturing

Healthy Inc is a premier ENT Pharmaceutical Exporter in India. As a verified Medicine Supplier in Mumbai, we offer flexible Third Party Manufacturing (Contract Manufacturing) for specialized Neuro-Vestibular Therapeutics. Whether you are an Audiology Clinic Network in Africa or a B2B Pharma Marketplace partner in Southeast Asia, we ensure secure, WHO-GMP compliant delivery.